VascularStrategies takes great pride and satisfaction in helping our clients from large, mid-size and small pharma companies, as well as academic collaborators, realize their research and development goals.

Select list of publications from the VascularStrategies Library
Changes in High-Density Lipoprotein Cholesterol Efflux Capacity After Bariatric Surgery Are Procedure Dependent.
Heffron SP, Lin BX, Parikh M, Scolaro B, Adelman SJ, Collins HL, Berger JS, Fisher EA.
Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):245-254. doi: 10.1161/ATVBAHA.117.310102. Epub 2017 Nov 21.
PMID: 29162605

Cholesterol Efflux Capacity, High-Density Lipoprotein Particle Number, and Incident Cardiovascular Events: An Analysis From the JUPITER Trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin).
Khera AV, Demler OV, Adelman SJ, Collins HL, Glynn RJ, Ridker PM, Rader DJ, Mora S.
Circulation. 2017 Jun 20;135(25):2494-2504. doi: 10.1161/CIRCULATIONAHA.116.025678. Epub 2017 Apr 27.
PMID: 28450350   Free PMC Article

Effects of the cholesteryl ester transfer protein inhibitor, TA-8995, on cholesterol efflux capacity and high-density lipoprotein particle subclasses.
van Capelleveen JC, Kastelein JJ, Zwinderman AH, van Deventer SJ, Collins HL, Adelman SJ, Round P, Ford J, Rader DJ, Hovingh GK.
J Clin Lipidol. 2016 Sep-Oct;10(5):1137-1144.e3. doi: 10.1016/j.jacl.2016.06.006. Epub 2016 Jun 25.
PMID: 27678430 [PubMed – in process]

Safety and Tolerability of ACP-501, a Recombinant Human Lecithin:Cholesterol Acyltransferase, in a Phase 1 Single-Dose Escalation Study.
Shamburek RD, Bakker-Arkema R, Shamburek AM, Freeman LA, Amar MJ, Auerbach B, Krause BR, Homan R, Adelman SJ, Collins HL, Sampson M, Wolska A, Remaley AT.
Circ Res. 2016 Jan 8;118(1):73-82. doi: 10.1161/CIRCRESAHA.115.306223. Epub 2015 Dec 1.
PMID: 26628614 [PubMed – indexed for MEDLINE] Free PMC Article

L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE(-/-) transgenic mice expressing CETP.
Collins HL, Drazul-Schrader D, Sulpizio AC, Koster PD, Williamson Y, Adelman SJ, Owen K, Sanli T, Bellamine A.
Atherosclerosis. 2016 Jan;244:29-37. doi: 10.1016/j.atherosclerosis.2015.10.108. Epub 2015 Nov 2.
PMID: 26584136 [PubMed – indexed for MEDLINE] Free Article

Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib.
Nicholls SJ, Ruotolo G, Brewer HB, Kane JP, Wang MD, Krueger KA, Adelman SJ, Nissen SE, Rader DJ.
J Am Coll Cardiol. 2015 Nov 17;66(20):2201-10. doi: 10.1016/j.jacc.2015.09.013.
PMID: 26564598 [PubMed – indexed for MEDLINE] Free Article

Increased plasma cholesterol esterification by LCAT reduces diet-induced atherosclerosis in SR-BI knockout mice.
Thacker SG, Rousset X, Esmail S, Zarzour A, Jin X, Collins HL, Sampson M, Stonik J, Demosky S, Malide DA, Freeman L, Vaisman BL, Kruth HS, Adelman SJ, Remaley AT.
J Lipid Res. 2015 Jul;56(7):1282-95. doi: 10.1194/jlr.M048629. Epub 2015 May 11.
PMID: 25964513 [PubMed – indexed for MEDLINE] Free PMC Article

Incubation of MDCO-216 (ApoA-IMilano/POPC) with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size.
Kempen HJ, Schranz DB, Asztalos BF, Otvos J, Jeyarajah E, Drazul-Schrader D, Collins HL, Adelman SJ, Wijngaard PL.
J Lipids. 2014;2014:923903. doi: 10.1155/2014/923903. Epub 2014 Nov 12.
PMID: 25478232 [PubMed] Free PMC Article

Effect of repeated apoA-IMilano/POPC infusion on lipids, (apo)lipoproteins, and serum cholesterol efflux capacity in cynomolgus monkeys.
Kempen HJ, Gomaraschi M, Bellibas SE, Plassmann S, Zerler B, Collins HL, Adelman SJ, Calabresi L, Wijngaard PL.
J Lipid Res. 2013 Sep;54(9):2341-53. doi: 10.1194/jlr.M033779. Epub 2013 Jul 4.
PMID: 23828780 [PubMed – indexed for MEDLINE] Free PMC Article

The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans.
Singaraja RR, Sivapalaratnam S, Hovingh K, Dubé MP, Castro-Perez J, Collins HL, Adelman SJ, Riwanto M, Manz J, Hubbard B, Tietjen I, Wong K, Mitnaul LJ, van Heek M, Lin L, Roddy TA, McEwen J, Dallinge-Thie G, van Vark-van der Zee L, Verwoert G, Winther M, van Duijn C, Hofman A, Trip MD, Marais AD, Asztalos B, Landmesser U, Sijbrands E, Kastelein JJ, Hayden MR.
Circ Cardiovasc Genet. 2013 Feb;6(1):54-62. doi: 10.1161/CIRCGENETICS.111.962613. Epub 2012 Dec 14.
PMID: 23243195 [PubMed – indexed for MEDLINE] Free Article